Drugs approved by the US FDA – including some1 trade names used overseas – to treat major depressive disorder (MDD) (as well as DSM-III and DSM-II variants and other conditions in the depression spectrum). Not all drugs are available under their brand name, and some overseas trade names are obsolete; both are included here to assist anyone who knows only the now-obsolete brand/trade names. These are grouped by US trade name2.


Asendin (amoxapine)

Brintellix (vortioxetine)

Celexa (citalopram)

chlordiazepoxide and amitriptyline



Eldepryl (selegiline)

  • selegiline
  • Emsam (selegiline transdermal system) / Emsam patch

Etrafon (amitriptyline and perphenazine)


Limbitrol (chlordiazepoxide and amitriptyline)Ludiomil (maprotiline)Manerix (moclobemide)maprotilineMarplan (isocarboxazid)moclobemideNardil (phenelzine)

Parnate (tranylcypromine)

perphenazine and amitriptylinephenelzine


Rexulti (brexpiprazole) – as an add-on to an antidepressantselegiline

Surmontil (trimipramine)

tranylcypromineTriavil (amitriptyline and perphenazine)trimipramine

Vivactil (protriptyline)

  • protriptyline

Drugs approved outside of the US, but not by the US FDA, to treat depression spectrum disorders:

  • agomelantine
  • amitriptylinoxide
  • Aurorix (moclobemide)
    • moclobemide
    • Manerix (moclobemide)
  • Deanxit (flupentixol and melitracen)
  • dibenzepine
  • dosulepin / dothiepin
  • Edronax (reboxetine)
  • etoperidone
  • flupentixol
  • Ixel (milnacipran)
  • lofepramine
  • melitracen
  • mianserin
  • moclobemide
  • nitroxazepine
  • noxiptiline
  • opipramol
  • pipofezine
  • pirlindole / pirasidol
  • Stablon (tianeptine) – Available in the US as a supplement.
  • tandospirone – AKA Japanese BuSpar
  • teniloxazine
  • thioridazine – Available in the US, but off-label prescribing is prohibited.
  • tianeptine
  • tofenacin
  • toloxatone
  • Tolvan (mianserin)
  • Valdoxan (agomelatine)
  • Vivalan (viloxazine)
    • viloxazine

Drugs commonly prescribed off-label to treat depression

  • Anafranil (clomimpramine) – Anafranil is a TCA, thus chemically classified as an antidepressant, but approved in the US to treat anxiety and not depression.
    • clomipramine
  • BuSpar (buspirone) – Used off-label as an add-on to an AD, or as monotherapy.
  • Lamictal (lamotrigine)
  • Latuda (lurasidone)
  • Lithobid
  • Eskalith
  • Lovaza (omega-3-acid ethyl esters)
  • Luvox (fluvoxamine) – Luvox, an SSRI and thus chemically classified as an antidepressant, is approved in the US to treat OCD, but not depression.
  • Provigil (modafinil)
    • modafinil
  • Ritalin (methylphenidate)
  • Savella (milnacipran) – Savella, an SNRI and thus chemically classified as an antidepressant, is approved in the US to treat fibromyalgia, but not depression.
  • Seroquel (quetiapine)
  • Strattera (atomoxetine) – like Anafranil, Luvox, and Savella, Strattera is chemically an antidepressant. It just isn’t approved as one.
  • Zyban (bupropion) – Bupropion isn’t approved in most countries as an antidepressant, only as an aid in smoking cessation. So it’s prescribed off-label for depression in those countries. While it shouldn’t be as much of an issue in the US today, it was often necessary for doctors to prescribe Zyban instead of Wellbutrin because some insurance plans wouldn’t cover psych meds.

Antidepressant Topic Index 
1 “Some” meaning “Mostly in countries where most of the people speak English,” because over 96% of the traffic to this site is from places where English is the primary language. I’m also including the more popular trade names used outside of the US, even if they’re in non-Latin character sets.

2 Again, because this is primarily an American site, and Google expects a hierarchy of brand name, generic name, alternate names and ingredient.